Read the following two articles and answer the questions below.

What is a ketogenic diet?

Using the Hierarchy of Evidence framework described during weeks 2 and 3, identify the study design used by Bueno et al.

What was the rationale for the study by Bueno et al?

How did Bueno et al define a very-low carbohydrate ketogenic diet? Low-fat diet?

Interpret results from the Bueno et al study (you can ignore the details of the statistical analysis and results of the sub-group analyses; just focus on the primary findings). In particular, how does a ketogenic diet impact markers of cardiovascular disease risk (i.e., body weight, TAG, HDL-cholesterol, LDL-cholesterol, systolic blood pressure, diastolic blood pressure)?

What are the biological mechanisms described in the discussion section of the Bueno et al article that may explain these findings?